Egyptologist Dr. Julius Kane accidentally unleashes the Egyptian god Set, who banishes the doctor to oblivion and forces his two children to embark on a dangerous journey to save him.
Carter and Sadie, offspring of the brilliant Egyptologist Dr. Julius Kane, embark on a worldwide search for the Book of Ra, but the House of Life and the gods of chaos are determined to stop them.
Carter and Sade prepare for the ultimate confrontation with the chaos snake Apophis at the same time the House of Life magicians launch a civil war, compelling the Kanes to tap the power of an ancient spell.